Protein splicing is an extraordinary post‐translational reaction that removes an intact central “spacer” domain (Sp) from precursor proteins (N‐Sp‐C) while splicing together the N‐ and C‐domains of the precursor, via a peptide bond, to produce a new protein (N‐C). All of the available data on protein splicing fit a model in which these intervening sequences excise at the protein level via a self‐splicing mechanism. Several proteins have recently been discovered that undergo protein splicing, and in two such cases, the excised (...) spacer protein is an endonuclease. Such endonucleases are capable of conferring genetic mobility upon the intervening sequences that encodes them. These intervening sequences define a new family of mobile genetic elements that are translated yet remain phenotypically silent by excising at the protein rather than the RNA level. (shrink)

This paper takes Franco's Spain to be a powerful case study for analyzing the ways in which power shapes science and technology and is shaped by them in return. Spain was the last country in Western Europe to establish closer links with any of the international cooperative institutions emerging after WWII. As such, developments internal to Spanish society were quite autonomous and relatively free from foreign influences. The paper focuses first on the brand new, powerful institution that the Francoist regime (...) created to promote scientific research under tight political control, the Consejo Superior de Investigaciones Científicas. Next it turns to applied science and technology, top priorities for the regime's state-supported programs of industrialization. They were implemented through the politically and financially powerful Instituto Nacional de Industria. Using diplomatic sources, the paper next argues that, until the late 1950s, Spain maintained substantial political and economic isolation essentially because the regime bet on autarkic policies and a model of largely isolated development. In this model, it was crucial for the regime to develop its own technological and scientific resources. Finally, the paper examines how the regime fostered a new Spanish identity in which science had a new role. (shrink)

Katz (1981, 1985) has denied the psychological import of Linguistics on the grounds of alleged inconsistencies that arise when Linguistics is conceived as a psychological enterprise, and proposed an alternative Platonistic conception. The paper discards the plausibility of this latter approach to the study of natural language but recognizes the difficulties Katz has pointed out. It is claimed that these difficulties appear if the “strong competence hypothesis” (Bresnan & Kaplan, 1982) is assumed, that is, if it is assumed that the (...) form of the speaker’s knowledge of language is that of a grammar. A weaker conception of the psychological relevance of linguisitic theories is proposed-one that avoids Katz’s difficulties, is more congenial to Chomsky, and clears the way for a fruitful cooperation between Linguistics and Psycholinguistics. (shrink)

The circumscribed quadrature of professional ethics aims to show the necessary shift from deontology to professional ethics, from deontological codes to ethical codes. While deontology and the deontological codes that materialise from it set their sights on professionals' responsibilities, professional ethics and the ethical codes that should derive from it would set their sights on the professional act, on its successful performance. In this way, the stress comes to be placed not only on the professional's responsibility, although that too, but (...) also on the necessary orchestration of the responsibilities shared at numerous levels by everyone involved in the performance of the professional act. The author identifies and typifies five elements present in the professional act. Four of them involve direct the protagonism of the professional, the recipient of the professional service, the institution that makes the service possible and from which the professionals' service is offered, and finally the human factor, the people who are behind the aforementioned factors and their nature, the professional, the recipient of the services and institutions. And each of these factors paves the way for a series of diversified protagonisms: inter-professional cooperation, receiver of professional services and their human environment around them, macro and micro institutions, diverse human profiles. However, all of this takes place within the framework of the fifth important element in professional ethics: a given, specific society as a circumscription of the four elements cited above, which sets the moral bar, a set of convictions and desired collective ethics which unquestionably also affect the performance of professional acts. With this reflection, we take note of the necessary co-responsibility in the provision of professional services, a co-responsibility which we could express simply in healthcare terms: it is not enough to merely have sound healthcare professionals if we do not have good patients with favourable affective environments, nor sound healthcare institutions, nor serious people who are socially committed to their work and their role, nor a society that believes in and fosters given identifiers of the personal and professional health to which we aim. The reflections in this proposal embark on a pathway of reflection which, we believe, deserves to be further explored. (shrink)

The paper presents the territorial and axiological context and the peculiarities of the participatory project developed by the Polis Research Centre and the Bon Pastor Neighbourhood Association, as well as the first steps in the design of two interventions. The first intervention, the Wall and Party Walls in Rodriguez de la Fuente Square, is proposed within the framework of the sustainable development strategies of Barcelona City Council. Its main objective is to achieve thermal insula­tion of the affected dwellings, thus contributing (...) to the well being of the residents and to the reduc­tion of CO 2 emissions into the atmosphere. Besides, it is aimed to solve landscape discontinuity. In the lower part of the party walls, there is a wall, a kind of plinth that the residents have chosen as a site for the expansion of the work on the civic remembrance of the neighbourhood. There, the “Living Memory” space will be set up, reserved for interventions by children from the quarter’s schools through a work programme run in cooperation with them. The second intervention is the case of the centennial Mulberry Tree classified as a tree of local interest. In 2018, the mulberry tree suffered some damage from thugs who threw firecrackers inside. Therefore, the need was pointed out to reorganise the space around the tree in order to create dissuasive effects and preserve its integrity. These are preliminary studies to be discussed by the agents involved in the project: the Sant Andreu District, the IMPUQV (Institut Municipal del Paisatge Urbài la Qualitat de Vida), and the Bon Pastor Neighbourhood Association. (shrink)

A cross-cultural analysis of trust and cooperation networks in Northern Ghana (NGHA) and Oaxaca (OAX) was carried out by means of ego networks and interviews. These regions were chosen because both are inhabited by several ethnic groups, thus providing a good opportunity to test the cultural group selection hypothesis. Against the predictions of this approach, we found that in both regions cooperation is grounded in personal trust groups, and that social cohesion depends on these emotional bonds. Moreover, in agreement with (...) Fiske's notion of “evolved proclivities”, we also found two distinct kinds of trust networks, one for each region, which vary in terms of the degree of ethnic interrelation. This pattern suggests that social cohesion increases when environmental resources are scarce. (shrink)

SummaryIn early and prehistoric times, human groups cooperated among themselves and competed viciously with other groups. Concepts of international relations, notably universal hegemony and exclusive nationalism, go back to the earliest recorded history. Only the ancient Greeks experienced inter-state relations somewhat analogous to those of modern Europe; and the first reflections on these may be found in Thucydides. The Greeks, and later the Romans, above all Cicero, developed a notion of cosmopolitanism. During the Latin Middle Ages, the papacy perpetuated the (...) idea of universal hegemony. The principle of state sovereignty was also formulated. The pre-modern Chinese empire was held to rule ‘all-under-Heaven’; Confucian ethics contributes the notion of humanity as the fundamental category. Muslims deepened the us–them distinction by claiming sole legitimacy for their religious community under the Caliph. Today, Muslims veer between this and a more Western approach to international relations. (shrink)

Katz has denied the psychological import of Linguistics on the grounds of alleged inconsistencies that arise when Linguistics is conceived as a psychological enterprise, and proposed an alternative Platonistic conception. The paper discards the plausibility of this latter approach to the study of natural language but recognizes the difficulties Katz has pointed out. It is claimed that these difficulties appear if the “strong competence hypothesis” is assumed, that is, if it is assumed that the form of the speaker’s knowledge of (...) language is that of a grammar. A weaker conception of the psychological relevance of linguisitic theories is proposed-one that avoids Katz’s difficulties, is more congenial to Chomsky, and clears the way for a fruitful cooperation between Linguistics and Psycholinguistics. (shrink)

Human Towers are one of the most representative traditional sporting games in Catalonia, recognized in 2010 as Intangible Cultural Heritage by the United Nations Organization for Education, Science and Culture. The objective of this research was to study the emotional states elicited by a representative performance of the colla de Castellers de Lleida. This research is based on an ethnographic case study, with mixed methods in which 17 key informants voluntarily participated. Participant observation was used; the data were recorded in (...) a field diary and oral sources. The content analysis was done using the Atlas.ti software. An SPSS database was also created. The statistical techniques were: Descriptive statistical techniques, cross tables with Pearson's Chi-square values. We also used a classification and regression trees to examine the predictive capacity of five independent variables of emotional states. The results reveal that the comments were mostly oriented toward well-being states, The internal cooperative logic of the Human Towers enhances the intense interpersonal relationships of socio-emotional well-being. (shrink)

The environmental complexity in which living organisms found themselves throughout evolution, most likely resulted in various encounters that would continuously challenge the organisms' ability to survive. Coping with this stress can prove energetically demanding and might require the proper coupling between mechanisms aimed at sensing external stimuli and cellular strategies geared at producing energy. In this issue of BioEssays, Lovejoy and Hogg hypothesize that preservation of this bifaceted coupling can be detected by the maintenance and evolution of stress response mechanisms (...) at the genomic, molecular and cellular levels. Through ancestry‐tracking, they identify a group of related G protein‐coupled receptor systems with intersecting stress‐modulating properties which might represent an essential part of a complex organism's coping mechanisms to stress, an attribute that they suspect may be affected in individuals suffering from mood disorders such as depression. (shrink)

It is a surprising fact that moral philosophers have rarely examined the distinction between what I shall call ‘positive’ or ‘social’ morality on the one hand and ‘autonomous’ or ‘individual’ morality on the other. Accordingly, conceptual and moral issues of the greatest importance have been neglected. The distinction is, I take it, recognised by Hegel, when he contrasts Sittlichkeit with Moralität . However, the rival sides who give a conceptual or a moral preference to one concept over the other rarely (...) come to grips with one another, and the deep conflicts between them are concealed instead of being brought out into the open. Only in Burke's diatribe against Rousseau, Bradley's critique of Sidgwick , Hobhouse's crusade against Bosanquet , Prichard's attack on Green , Hart's criticism of Hare , and above all in Oakeshott's onslaught on Rationalism do we get a glimpse of one of the main issues of moral philosophy and of morality. For just as we have two concepts, so we have two moral conceptual schemes, each of which gives a central place to one concept at the expense of the other. Those who suppose that morality is or ought to be wholly or mainly a social concept may recommend submission to a tradition. Those, on the other hand, who suppose morality to be primarily an individual or independent concept will recommend independent decisions. I want in this paper, firstly, to explain the differences between the two concepts, secondly, to show that neither of them is conceptually illegitimate or degenerate, and lastly, to determine what place, if any, each ought to have in a rational morality. (shrink)

Our concept of disorder is changing. This causes problems for projects of descriptive conceptual analysis. Conceptual change means that a criterion that was necessary for a condition to be a disorder at one time may cease to be necessary a relatively short time later. Nevertheless, some conceptually based claims will be fairly robust. In particular, the claim that no adequate account of disorder can appeal only to biological facts can be maintained for the foreseeable future. This is because our current (...) concept of disorder continues to be laden with ethical and political values in multiple ways. (shrink)

This book collects some of the most exciting pioneering work in perceptual and cognitive psychology. The authors' quantitative approach to the study of mental images and their representation is clearly depicted in this invaluable volume of research which presents, interprets, evaluates, and extends their work. The selections are preceded by a thorough review of the history of their experiments, and all of the articles have been updated with reviews of the current literature. The book's first part focuses on mental rotation; (...) the second includes other, more complex transformations and sequences of transformations. A third part describes work on rotational transformations in the context of the perceptual illusion of &"apparent motion.&" Roger N. Shepard is Professor of Psychology, Stanford University. Lynn A. Cooper is Professor of Psychology, University of Arizona. A Bradford Book. (shrink)

ABSTRACT The paper examines J. Glover's 1970 account of the evasion of responsibility. Attention is focused on the Eichmann case and Glover's contention that moral condemnation of Eichmann depends on the view that there is a duty to submit one's actions to moral criticism. Two uses of the word ‘moral’ are distinguished (one use for moral commitment, the other for logical diagnosis) and it is argued that Glover's thesis is accordingly ambiguous. It is contended that Glover must either abandon his (...) stipulative account of the concept of morality or accept the objectivity of moral judgements or modify his unqualified thesis that everybody ought to submit his conduct to moral criticism. An account of problems of evading responsibility involves us, it is maintained, in an area of moral philosophy, the Dialectic of Morals, where knock‐down arguments are sparse. (shrink)

To understand the mind, we need to draw equally on the fields of cognitive science and neuroscience. But these two fields have very separate intellectual roots, and very different styles. So how can these two be reconciled in order to develop a full understanding of the mind and brain.This is the focus of this landmark new book.

We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)

In my 1993 IJPS paper it was suggested that postmodernist verdicts on ‘the death of philosophy’ relied on a rejection of any ‘substantive’ or ‘metaphysical’ notion of truth. The present paper relates these verdicts to Wittgenstein’s alleged ‘philosophical quietism’. In both cases, for example, there is a rejection of ‘depth’. Various characterisations of Wittgenstein’s position are questioned, including the idea that his quietism consists in showing the impossibility of sceptical challenges to our ‘hinge’ propositions and beliefs. It is then argued, (...) however, that recognition of the groundlessness of beliefs (and practices), far from curing ‘vertigo’ or ‘Angst’, is apt to inspire it. In a final section, I propose that the ‘metaphysical horror’ at the impossibility of articulating grounds for our beliefs can be allayed only by the thought that these answer to a reality that cannot be articulated and must therefore remain a mystery. One role for philosophy might be to cultivate a sense of this mystery and trace its implications for how we should live. (shrink)

The chapter challenges hyperbolic claims about the centrality of appreciation of beauty to Buddhism. Within the texts, attitudes are more mixed, except for a form of 'inner beauty' - the beauty found in the expression of virtues or wisdom in forms of bodily comportment. Inner beauty is a stable presence throughout Buddhist history, practices, and art.

R. S. Peters has not only been the major philosopher of education in Britain during second half of the twentieth century, but by common consent, he has transformed the subject and brought it into the mainstream of contemporary philosophy. The ten essays in this book attest to his influence whether by critical examination of his ideas or by original treatment of topics in which has has inspired a new interest.

This book is a sustained examination of issues in the philosophy of ecology that have been a source of controversy since the emergence of ecology as an explicit scientific discipline. The controversies revolve around the idea of a balance of nature, the possibility of general ecological knowledge and the role of model-building in ecology. The Science of the Struggle for Existence is also a detailed treatment of these issues that incorporates both a comprehensive investigation of the relevant ecological literature and (...) the development of an explicit theoretical framework in the philosophy of science. It addresses issues in the philosophy of ecology that are of particular importance for the deployment of ecology in the solution of environmental problems. It will have a cross-disciplinary appeal and will interest students and professionals in science, the philosophy of science, and environmental studies as well as policy-makers. (shrink)

In 1924, not quite two years after receiving his doctorate from the University of Vienna, Eric Voegelin was named a Laura Spelman Rockefeller Memorial Fellow and thus given the opportunity to pursue postdoctoral studies in the United States. For the next twenty-four months, Voegelin worked with some of the most creative scholars in America and at several of the country's great universities, an experience that undoubtedly influenced his scholarly and personal perspectives throughout his life. A more immediate result was the (...) publication in 1928 of _On the Form of the American Mind,_ the young philosopher's first major work, in which his acute perceptions and analyses combine with a conceptual vocabulary struggling to find its own coherence and form. Voegelin begins his inquiry into the form of the American mind with a complex discussion of the concepts of time and existence in European and American philosophy and continues with an extended interpretation of George Santayana, a study of the Puritan mystic Jonathan Edwards, a presentation on Anglo-American jurisprudence, and a consideration of the historian, economist, and political scientist John R. Commons. Although admitting that this diversity of themes seems only loosely connected," Voegelin demonstrates the actual overall unity of these various subjects: each concerns linguistic expressions of a theoretical nature. Analysis of _On the Form of the American Mind_ indicates that Voegelin integrated the approaches of _Lebensphilosophie_ into what Georg Misch called the "philosophical combination of anthropology and history," which characterized contemporary trends within the discourse of the _Geisteswissenschaften_ and finally resulted in a theoretical paradigm of philosophical anthropology. Jürgen Gebhardt and Barry Cooper provide access to this brilliant study with their two-part introduction. The first part considers _On the Form of the American Mind_ in the context of methodological debates ongoing in Germany at the time Voegelin was writing the book; the second describes Voegelin's American experience and compares his work with similar studies written during the post-World War I period. (shrink)

We investigate whether small perturbations can cause relaxation to quantum equilibrium over very long timescales. We consider in particular a two-dimensional harmonic oscillator, which can serve as a model of a field mode on expanding space. We assume an initial wave function with small perturbations to the ground state. We present evidence that the trajectories are highly confined so as to preclude relaxation to equilibrium even over very long timescales. Cosmological implications are briefly discussed.

Philosophers of biology claim that function talk is consistent with naturalism. Yet recent work in biology places new pressure on this claim. An increasing number of biologists propose that the existence of functions depends on the organisation of systems. While systems are part of the domain studied by physics, they are capable of interacting with this domain through organising principles. This is to say that a full account of biological function requires teleology. Does naturalism preclude reference to teleological causes? Or (...) are organised systems precisely a naturalised form of teleology? In this paper I suggest that the biology of organised systems reveals several contradictions in the main philosophical conceptions of naturalism. To integrate organised systems with naturalism’s basic assumptions—that there is no theory-independent view for metaphysics, and that nature is intelligible—I propose an idealist solution. (shrink)

The logical properties of the 'if-then' connective of ordinary English differ markedly from the logical properties of the material conditional of classical, two-valued logic. This becomes apparent upon examination of arguments in conversational English which involve (noncounterfactual) usages of if-then'. A nonclassical system of propositional logic is presented, whose conditional connective has logical properties approximating those of 'if-then'. This proposed system reduces, in a sense, to the classical logic. Moreover, because it is equivalent to a certain nonstandard three-valued logic, its (...) decision procedure is almost as efficient as that of the classical logic. It therefore provides a rational and convenient system in which to formalize English arguments. (shrink)

NEITHER in the scholarly nor in the philosophical literature on Aristotle does his account of friendship occupy a very prominent place. I suppose this is partly, though certainly not wholly, to be explained by the fact that the modern ethical theories with which Aristotle’s might demand comparison hardly make room for the discussion of any parallel phenomenon. Whatever else friendship is, it is, at least typically, a personal relationship freely, even spontaneously, entered into, and ethics, as modern theorists tend to (...) conceive it, deals rather with the ways in which people are required to regard, and behave toward, one another, than with the organization of their private affairs. To the extent, then, that one shares this modern outlook one will tend to neglect, or treat merely as an historical curiosity, Aristotle’s efforts to define friendship and to place it within the framework of human eudaimonia, the theory of which is central to moral philosophy as he understands it. Yet in the Nicomachean Ethics the two books on φιλία make up nearly a fifth of the whole, and this seems to me a fair measure of the importance of this subject to the complete understanding both of Aristotle’s overall moral theory and even of many of the more circumscribed topics to which so much scholarly and philosophical attention has been devoted. If, as I suggest, the failure of commentators to appreciate its importance is partly the effect of distortions produced by the moral outlook that has predominated in modern moral philosophy, the careful study of these books may help to free us from constricting prejudices and perhaps even make it possible to discover in Aristotle a plausible and suggestive alternative to the theories constructed on the narrower base characteristic of recent times. (shrink)

This paper examines what it is for a condition to be a disease. It falls into two sections. In the first I examine the best existing account of disease (as proposed by Christopher Boorse) and argue that it must be rejected. In the second I outline a more acceptable account of disease. According to this account, by disease we mean a condition that it is a bad thing to have, that is such that we consider the afflicted person to have (...) been unlucky, and that can potentially be medically treated. All three criteria must be fulfilled for a condition to be a disease. The criterion that for a condition to be a disease it must be a bad thing is required to distinguish the biologically different from the diseased. The claim that the sufferer must be unlucky is needed to distinguish diseases from conditions that are unpleasant but normal, for example teething. Finally, the claim that for a condition to be a disease it must be potentially medically treatable is needed to distinguish diseases from other types of misfortune, for example economic problems and legal problems. (shrink)

This article offers a thorough analysis of the unintended impact economic sanctions have on political repression—referred to in this study as the level of the government respect for democratic freedoms and human rights. We argue that economic coercion is a counterproductive policy tool that reduces the level of political freedoms in sanctioned countries. Instead of coercing the sanctioned regime into reforming itself, sanctions inadvertently enhance the regime’s coercive capacity and create incentives for the regime’s leadership to commit political repression. Cross-national (...) time series data support our argument, confirming that the continued use of economic sanctions (even when aimed at promoting political liberalization and respect for human rights) will increase the level of political repression. These findings suggest that both scholars and policy makers should pay more attention to the externalities caused by economic coercion. (shrink)

Many students who sign up for undergraduate‐level philosophy arrive with the expectation that moral philosophy is concerned with how one should act in the concrete and familiar situations of everyday life. Yet moral philosophers are often motivated by an ideal of neutrality, and adopt a detached perspective to achieve a scientific view of the competing moral theories. To concretise the points of disagreement they present highly specific examples that are abstracted from daily reality. There is something odd about the image (...) of morality that comes into view. What kind of guidance about how to act in concrete and familiar situations can this form of theorising bring about? This paper examines Iris Murdoch’s account of moral perception as an alternative starting point. Murdoch offers a perspective that is conceptually prior to the separation of thought from action, one that addresses the agent on the level of perception. While accounts of moral perception are often criticized for proposing a complacent moral theory that is inherently conservative, I argue that Murdoch’s account offers a radical – or tragic – form of perfectionism. While moral philosophy cannot provide sufficient reasons to act, Murdoch shows that it can, like art, make us practical, capable of acting. (shrink)

Environmental health remains a niche topic in bioethics, despite being a prominent social determinant of health. In this paper we argue that if bioethicists are to take the project of health justice as a serious one, then we have to address environmental injustices and the threats they pose to our bioethics principles, health equity, and clinical care. To do this, we lay out three arguments supporting prioritizing environmental health in bioethics based on bioethics principles including a commitment to vulnerable populations (...) and justice. We also highlight and advocate for environmental law efforts that align with these priorities, focusing specifically on the need for a right to a healthy environment. Our intention is to draw attention to the legal and ethical concepts that underlie the importance of a healthy environment, and urge bioethicists to prioritize both legal and ethical advocacy against environmental injustices in their practice. (shrink)

There is a global shortage of organs for transplantation and despite many governments making significant changes to their organ donation systems, there are not enough kidneys available to meet the demand. This has led scientists and clinicians to explore alternative means of meeting this organ shortfall. One of the alternatives to human organ transplantation is xenotransplantation, which is the transplantation of organs, tissues, or cells between different species. The resurgence of interest in xenotransplantation and recent scientific breakthroughs suggest that genetically-engineered (...) pigs may soon present a realistic alternative as sources of kidneys for clinical transplantation. It is therefore important for nurses and allied health professionals to understand what is involved in xenotransplantation and its future implications for their clinical practices. First, we explore the insufficiency of different organ donation systems to meet the kidney shortage. Second, we provide a background and a summary of the progress made so far in xenotransplantation research. Third, we discuss some of the scientific, technological, ethical, and economic issues associated with xenotransplantation. Finally, we summarise the literature on the attitudes of healthcare professionals toward xenotransplantation. (shrink)

This paper investigates a sibling metaphor central to Rosenzweig’s reading of the Song of Songs in The Star of Redemption, in which the lovers yearn to be united in societal fraternity. His interpretation is marked by fraternal tropes and the subsequent effacement of gender. Rosenzweig transposes the erotic energy in the Song from a celebration of difference to a longing for sameness, a move that has exegetical, philosophical, and theological implications. Ultimately, the erotic sphere of revelation is surpassed by neighborly (...) “brotherliness” in communal redemption. (shrink)

We have sketched how it is possible to give an analysis for adjoined relative clauses which is consistent with the compositionality principle and have shown that the technique which seems necessary for this analysis can be used to provide a compositional semantics for the NP-S analysis of English relative clauses.It is unlikely that anyone working within the framework of a compositional theory would choose the NP-S analysis for English, since it is clearly much less elegant and simple, in some intuitive (...) sense, than the alternative Nom-S analysis. Our results seem to indicate, however, that such an analysis cannot be ruled out in principle, since any constraint on the theory that would exclude the NP-S analysis would seem to exclude the Hittite analysis as well. So the arguments for the Nom-S analysis in the English case must be based on other grounds, or the Hittite analysis is also incorrect and should be ruled out, or the happy discovery of some as yet unknown principles will allow one but not the other. (shrink)

This article explores the challenge of developing a feminist law reform proposal to decertify sex and gender based on research conducted for the ‘Future of Legal Gender' project. Locating the proposal to decertify within a do-it-yourself, prefigurative approach to law reform, the article asks: Can a law reform proposal be both instrumental and radical? Can a proposal take shape as a viable legislative text and as a more subversive intervention to unsettle and reimagine gender’s relationship to law? This article explores (...) this at two levels. First, it considers the ontological challenges of developing a controversial law reform proposal in terms of its realness (or fictiveness), contours, and temporality, turning to ‘slow law' as a credible way of approaching radical reform. Second, it explores the design-based challenges of legal prototyping—foregrounding questions of legitimacy, participation, and purpose, which arise in designing a decertification law. At the heart of this discussion is the relationship between representation and enactment—between what a proposal presents and what its presentation does and does not accomplish. (shrink)

The debate over abortion tends to be framed as life versus choice. Yet, neither pole matches the actual experiences of women, especially women of colour and poor women. Using the hermeneutical circle from the perspective of Christian liberation theology, this article argues that beginning with the voices of those marginalized in the debate leads us to a broader conversation of reproductive justice, which requires an analysis of reproduction as a whole. The article focuses on what constrains the ability of women (...) and men to choose whether to have children, across the spectrum from contraception to abortion to fetus selection. (shrink)

This collection of Habermas's recent essays on philosophical topics continues the analysis begun in The Philosophical Discourse of Modernity. In a short introductory essay, he outlines the sources of twentieth-century philosophizing, its major themes, and the range of current debates. The remainder of the essays can be seen as his contribution to these debates.Habermas's essay on George Herbert Mead is a focal point of the book. In it he sketches a postmetaphysical, intersubjective approach to questions of individuation and subjectivity. In (...) other essays, he develops his distinctive, communications-theoretic approach to questions of meaning and validity. The book as a whole expands on his earlier efforts to define a middle ground between nostalgic revivals of metaphysical conceptions of reason and radical deconstructions of reason. Jürgen Habermas is Professor of Philosophy at the University of Frankfurt.The Essays: The Horizon of Modernity is Shifting. Metaphysics after Kant. Themes in Postmetaphysical Thinking. Toward a Critique of the Theory of Meaning. Peirce and Communication. The Unity of Reason in the Diversity of Its Voices. Individuation through Socialization: On George Herbert Mead's Theory of Subjectivity. Philosophy and Science as Literature? (shrink)

What would my life have been like if I had been born more intelligent? Or taller? Or a member of the opposite sex? Or a non-biological being? It is plausible that some of these questions make sense, while others stretch the limits of sense making. In addressing questions of how I might have been, genetic essentialism is popular, but this article argues that genetic essentialism, and other versions of origin essentialism for organisms, must be rejected. It considers the prospects for (...) counterpart theory and shows how counterpart theory can be used to illuminate volitional accounts of identity as proposed by Harry Frankfurt. This enables one to make sense of claims that, say, being gay, or Deaf, or Black, can be essential to someone's identity. The discussion is then extended to show how it can be made applicable to the transworld identity theorist who denies that individuals possess essential properties. (shrink)

This paper examines how a person’s life may be shaped by living with a sense of the mystery of reality. What virtues, if any, are encouraged by such a sense? The first section rehearses a radical ”doctrine of mystery’, according to which reality as it anyway is, independently of human perspectives, is ineffable. It is then argued that a sense of mystery may provide ”measure’ for human lives. For it is possible for a life to be ”consonant’ with this sense (...) -- through exercising humility, for example -- and even to emulate mystery. A further section corrects a misunderstanding about the connection between a sense of mystery and the virtues it invites, while a final section considers the relationship between living with mystery and religious faith. (shrink)

Núñez et al. (2019) argue that cognitive science has failed either “to transition to a mature inter‐disciplinary coherent field” (p. 782) or “to generate a successful [Lakatosian] research program” (p. 789). We argue that the former was never the intention of many early researchers within the field, while the latter is an inappropriate criterion by which to judge an entire discipline. However, we concur with Núñez et al. (2019) that the individual disciplinary balance within cognitive science has changed over time. (...) Of particular concern is the fact that the use of computational methods appears to be on the wane. (shrink)

is a term introduced by Ian Hacking to refer to the kinds of people—child abusers, pregnant teenagers, the unemployed—studied by the human sciences. Hacking argues that classifying and describing human kinds results in feedback, which alters the very kinds under study. This feedback results in human kinds having histories totally unlike those of natural kinds (such as gold, electrons and tigers), leading Hacking to conclude that human kinds are radically unlike natural kinds. Here I argue that Hacking's argument fails and (...) that he has not demonstrated that human kinds cannot be natural kinds. Introduction Natural kinds Hacking's feedback mechanisms 3.1 Cultural feedback 3.2 Conceptual feedback. (shrink)

The development of analogical reasoning has traditionally been understood in terms of theories of adult competence. This approach emphasizes structured representations and structure mapping. In contrast, we argue that by taking a developmental perspective, analogical reasoning can be viewed as the product of a substantially different cognitive ability – relational priming. To illustrate this, we present a computational (here connectionist) account where analogy arises gradually as a by-product of pattern completion in a recurrent network. Initial exposure to a situation primes (...) a relation that can then be applied to a novel situation to make an analogy. Relations are represented as transformations between states. The network exhibits behaviors consistent with a broad range of key phenomena from the developmental literature, lending support to the appropriateness of this approach (using low-level cognitive mechanisms) for investigating a domain that has normally been the preserve of high-level models. Furthermore, we present an additional simulation that integrates the relational priming mechanism with deliberative controlled use of inhibition to demonstrate how the framework can be extended to complex analogical reasoning, such as the data from explicit mapping studies in the literature on adults. This account highlights how taking a developmental perspective constrains the theory construction and cognitive modeling processes in a way that differs substantially from that based purely on adult studies, and illustrates how a putative complex cognitive skill can emerge out of a simple mechanism. (shrink)

The DSM is the main classification of mental disorders used by psychiatrists in the United States and, increasingly, around the world. Although widely used, the DSM has come in for fierce criticism, with many commentators believing it to be conceptually flawed in a variety of ways. This paper assesses some of these philosophical worries. The first half of the paper asks whether the project of constructing a classification of mental disorders that ‘cuts nature at the joints’ makes sense. What is (...) mental disorder? Are types of mental disorder natural kinds (that is, are the distinctions between them objective and of fundamental theoretical importance, as are, say, the distinctions between the chemical elements)? The second half of the paper addresses epistemic worries. Even if types of mental disorder are natural kinds there may be reason to doubt that the DSM will come to reflect their natural structure. In particular, I examine the extent to which the DSM is theory-laden, and look at how it has been shaped by social and financial factors. Ultimately, I conclude that although the DSM is of immense practical importance it is not likely to become the best possible classification of mental disorders. (shrink)

Public health decisions made by the state involve considerable disagreements on the course of actions, uncertainties, and compromises that arise from moral tensions between the demands of civil liberties and the goals of public health. With such complex decisions, it can be extremely difficult to arrive at and justify the best option. In this article, we propose an ethical decision-making framework based on the philosophy of Ubuntu and argue that in sub-Saharan African settings, this approach provides attractive alternative conventions of (...) moral decision-making and a useful language for understanding moral reasoning and ethics. Through its emphasis on humanity, compassion, and social responsibility, Ubuntu (“I am because we are”) has the potential to facilitate solutions to and avert conflicts between individual rights and public health. The use of Ubuntu shifts the moral reasoning and ethics of decision-making from a field of philosophy shaped by the global north, to the everyday values, decision-making, and consequent practices of people in much of Africa. Using examples of Ebola, pandemic influenza, and tuberculosis, we illustrate how Ubuntu can be applied to tackle conflicting ethical problems in public health and medicine. (shrink)